Impaired brain metabolism and neurocognitive function in childhood leukemia survivors despite complete hormone supplementation in adulthood
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- 作者：Cecilia Follina ; Cecilia.follin@med.lu.se" class="auth_mail" title="E-mail the corresponding author ; Eva Marie Erfurtha ; Aki Johanssonb ; Jimmy Lä ; ttc ; Pia C. Sundgrenc ; Kai Ö ; sterbergd ; Gabriella Spulbere ; Peter Mannfolkc ; Isabella M. Bjö ; rkman-Burtscherc ; f
- 关键词：Acute lymphoblastic leukemia ; Cranial radiotherapy ; Brain metabolism ; Magnetic resonance spectroscopy ; Neurocognitive function ; Childhood leukemia ; Cranial radiotherapy ; Neurocognitive function ; Neuropsychology ; MR-spectroscopy
- 刊名：Psychoneuroendocrinology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：73
- 期：Complete
- 页码：157-165
- 全文大小：1171 K
文摘
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Impaired brain metabolism and neurocognitive impairment in childhood ALL survivors.
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Reduced brain volumes in childhood ALL survivors.
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Impairment of metabolites correlated to time since treatment.
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We also report a progressive impairment in sustained attention, suggesting an accelerated aging in ALL survivors.