USP44 Is an Integral Component of N-CoR that Contributes to Gene Repression by Deubiquitinating Histone H2B

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• 作者：Xianjiang Lan¹ ; ² ; ³ ; Boyko S. Atanassov¹ ; ² ; Wenqian Li¹ ; ² ; ³ ; Ying Zhang⁴ ; Laurence Florens⁴ ; Ryan D. Mohan⁵ ; Paul J. Galardy⁶ ; Michael P. Washburn⁴ ; ⁷ ; Jerry L. Workman⁴ ; Sharon Y.R. Dent¹ ; ² ; ⁸ ; ^{sroth@mdanderson.org}
• 关键词：H2B ubiquitination ; USP44 ; N-CoR ; breast cancer ; transcription
• 刊名：Cell Reports
• 出版年：2016
• 出版时间：22 November 2016
• 年：2016
• 卷：17
• 期：9
• 页码：2382-2393
• 全文大小：2397 K
• 卷排序：17

文摘

USP44 is an integral subunit of the N-CoR complex USP44 associates with N-CoR through direct interaction with TBL1X/TBL1XR1 USP44 contributes to N-CoR-mediated repression of target genes USP44 or TBL1XR1 ablation impairs the invasiveness of breast cancer cells