The Xp10 Bacteriophage Protein P7 Inhibits Transcription by the Major and Major Variant Forms of the Host RNA Polymerase via a Common Mechanism
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- 作者：D.R. Brown ; drbrown@imperial.ac.uk" class="auth_mail" title="E-mail the corresponding author ; C.M. Sheppard ; L. Burchell ; S. Matthews ; S. Wigneshweraraj ; s.r.wig@imperial.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：RNAP ; RNA polymerase ; RPc ; closed promoter complex ; RPo ; open promoter complex ; β&prime ; NTD ; amino-terminal domain of the β&prime ; subunit ; CBD ; core binding domain EMSA ; Electrophoretic Mobility Shift Assay
- 刊名：Journal of Molecular Biology
- 出版年：2016
- 出版时间：9 October 2016
- 年：2016
- 卷：428
- 期：20
- 页码：3911-3919
- 全文大小：675 K
文摘
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Xp10 phage transcription regulator P7 inhibits transcription by RNAP containing σ54.
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P7 prevents the productive engagement of the σ54–RNAP with the promoter DNA.
• P7 disrupts preformed σ54–RNAP-promoter complexes.