Urinary exosome miRNome analysis and its applications to salt sensitivity of blood pressure

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• 作者：John J. Gildea ; Julia M. Carlson ; Cynthia D. Schoeffel ; Robert M. Carey ; Robin A. Felder
• 关键词：MAP ; mean arterial pressure ; BP ; blood pressure ; SS ; salt-sensitive ; SR ; salt-resistant ; ISS ; inverse salt-sensitive
• 刊名：Clinical Biochemistry
• 出版年：2013
• 出版时间：August, 2013
• 年：2013
• 卷：46
• 期：12
• 页码：1131-1134
• 全文大小：681 K

文摘

Objectives

To investigate microRNAs (miRNAs) in urinary exosomes and their association with an individual's blood pressure response to dietary salt intake.

Design and methods

Human urinary exosomal miRNome was examined by microarray.

Results

Of 1898 probes tested, 194 miRNAs were found in all subjects tested. 45 miRNAs had significant associations with salt sensitivity or inverse salt sensitivity.

Conclusion

The expression of 45 urinary exosomal miRNAs associates with an individual's blood pressure response to sodium.