Presenilin-1 familial Alzheimer鈥檚 disease mutation alters hippocampal neurogenesis and memory function in CCL2 null mice
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- 作者：Tomomi Kiyota ; tkiyota@unmc.edu" class="auth_mail" title="E-mail the corresponding author ; Christine M. Morrison ; Guihua Tu ; Bhagyalaxmi Dyavarshetty ; Robert A. Weir ; Gang Zhang ; Huangui Xiong ; Howard E. Gendelman
- 关键词：Hippocampus ; Neurogliogenesis ; Chemokine ; Morris water maze ; Long-term potentiation
- 刊名：Brain, Behavior, and Immunity
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：49
- 期：Complete
- 页码：311-321
- 全文大小：3882 K
文摘
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Generation of a novel mouse containing the presenilin 1 FAD mutation in a CCL2 knock out background.
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The murine model is associated with abnormal hippocampal neurogenesis and synaptic plasticity.
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Significant aging-dependent impairments in learning and memory are operative.