Normalizing Microbiota-Induced Retinoic Acid Deficiency Stimulates Protective CD8+ T Cell-Mediated Immunity in Colorectal Cancer
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- 作者：Nupur Bhattacharya1 ; 6 ; nupur26@stanford.edu" class="auth_mail" title="E-mail the corresponding author ; Robert Yuan1 ; 6 ; Tyler R. Prestwood1 ; 2 ; Hweixian Leong Penny1 ; Michael A. DiMaio3 ; Nathan E. Reticker-Flynn1 ; Charles R. Krois4 ; Justin A. Kenkel1 ; Tho D. Pham1 ; Yaron Carmi1 ; Lorna Tolentino1 ; Okmi Choi1 ; Reyna Hulett1 ; Jinshan Wang4 ; Daniel A. Winer5 ; Joseph L. Napoli4 ; Edgar G. Engleman1 ; 7 ; edgareng@stanford.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Immunity
- 出版年：2016
- 出版时间：20 September 2016
- 年：2016
- 卷：45
- 期：3
- 页码：641-655
- 全文大小：4921 K
文摘
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atRA deficiency in colon cancer is driven by microbiota-induced inflammation
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Treatment with atRA reduces tumorigenesis by enhancing a CD8+ T cell response
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The enhanced CD8+ T cell response is due to upregulation of MHCI on tumor cells
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CD8+ T cell cytotoxicity in human colon cancer correlates with local atRA metabolism