Loss of nuclear BAP1 protein expression is a marker of poor prognosis in patients with clear cell renal cell carcinoma
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- 作者：Daniele Minardi ; M.D.a ; 1 ; d.minardi@gostec.net" class="auth_mail" title="E-mail the corresponding author ; Guendalina Lucarini ; Ph.D.b ; 1 ; Giulio Milanese ; M.D.a ; Roberto Di Primio ; M.D.b ; Rodolfo Montironi ; M.D.c ; Giovanni Muzzonigro ; M.D.a
- 关键词：BAP1 protein ; Clear cell renal cell carcinoma ; Immunohistochemistry ; Cancer-specific survival
- 刊名：Urologic Oncology: Seminars and Original Investigations
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：34
- 期：8
- 页码：338.e11-338.e18
- 全文大小：2156 K
文摘
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We assessed prognostic value of BAP1 expression in terms of patients׳ survival.
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BAP1 immunohistochemical expression in ccRCC was correlated with clinical features.
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Nuclear BAP1 expression is a marker of prognosis rather than cytoplasmic expression.
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BAP1 could be useful to identify new targeted therapies.
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BAP1 could be useful to indentify approaches in the adjuvant and metastatic setting.