GPR17 is a promiscuous class-A GPCR operated by different ligand families.
The chemokine receptor ligand SDF-1 interacts with GPR17 via an extended network.
SDF-1 binding to GPR17 activates intracellular heterotrimeric Gi protein pathway.
GPR17 activation by SDF-1 promotes maturation of oligodendrocyte precursor cells.
Cangrelor competitively antagonizes SDF-1 activation of GPR17.