Mass spectrometry imaging for drugs and metabolites

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• 作者：Tyler  ; Greer^a ; Robert  ; Sturm^a ; Lingjun  ; Li ;   ; ^a ;   ; ^{lli@pharmacy.wisc.edu}
• 关键词：Drug ; Pharmaceuticals ; Metabolite ; MALDI ; SIMS ; NIMS ; DESI ; LAESI ; Mass spectrometry ; Imaging mass spectrometry (IMS) ; Mass spectrometric imaging (MSI)
• 刊名：Journal of Proteomics
• 出版年：2011
• 出版时间：18 November 2011
• 年：2011
• 卷：74
• 期：12
• 页码：2617-2631
• 全文大小：2014 K

文摘

Mass spectrometric imaging (MSI) is a powerful analytical technique that provides two- and three-dimensional spatial maps of multiple compounds in a single experiment. This technique has been routinely applied to protein, peptide, and lipid molecules with much less research reporting small molecule distributions, especially pharmaceutical drugs. This review's main focus is to provide readers with an up-to-date description of the substrates and compounds that have been analyzed for drug and metabolite composition using MSI technology. Additionally, ionization techniques, sample preparation, and instrumentation developments are discussed.