Unique study addressing the impact of antigen nitration in EAE/MS Nitrated MOG is poorly encephalitogenic in H2b C57BL/6 mice. The nitrated MOG35–55p40NIY altered peptide ligand does not induce EAE. H2q mice remain fully susceptible to EAE with nitrated MOG (MHC-dependent effect!). Mechanism explained using molecular MHC modeling.