Antimicrobial activity of ceftaroline and comparator agents when tested against numerous species of coagulase-negative Staphylococcus causing infection in US hospitals

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• 作者：Helio S. Sader ; ^{helio-sader@jmilabs.com" class="auth_mail" title="E-mail the corresponding author} ; David J. Farrell ; Robert K. Flamm ; Jennifer M. Streit ; Rodrigo E. Mendes ; Ronald N. Jones
• 关键词：Bloodstream infection ; Bacteremia ; Staphylococcus epidermidis ; Staphylococcus lugdunensis ; Skin and skin structure infection
• 刊名：Diagnostic Microbiology & Infectious Disease
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：85
• 期：1
• 页码：80-84
• 全文大小：208 K

文摘

A total of 1593 coagulase-negative staphylococci (CoNS) considered clinically significant were collected from 71 US medical centers in 2013–2014 and tested for susceptibility by CLSI broth microdilution methods. Species identification was performed by matrix-assisted laser desorption ionization–time-of-flight mass spectrometry. Overall, 59.7% of isolates were oxacillin resistant (MRCoNS). Ceftaroline (MIC_50/90, 0.25/0.5 μg/mL) inhibited 99.2% of CoNS at ≤1 μg/mL (susceptible breakpoint for Staphylococcus aureus), including 98.7% of MRCoNS, and the highest ceftaroline MIC value was 2 μg/mL (13 isolates). Staphylococcus epidermidis represented 60.3% of the CoNS collection and was highly susceptible to ceftaroline (MIC_50/90, 0.25/0.5 μg/mL, 99.9% inhibited at ≤1 μg/mL). All isolates of Staphylococcus capitis, Staphylococcus caprae, Staphylococcus hominis, Staphylococcus lugdunensis, Staphylococcus pettenkoferi, Staphylococcus simulans, and Staphylococcus warneri (MIC_50/90, 0.06–0.25/0.25–0.5 μg/mL) were inhibited at ceftaroline MIC of ≤1 μg/mL. Staphylococcus haemolyticus represented only 4.8%, was atypically less susceptible to ceftaroline (MIC_50/90, 0.5/2 μg/mL, 87.0% inhibited at ≤1 μg/mL), and accounted for 76.9% (10/13) of isolates with ceftaroline MIC >1 μg/mL.