Antimicrobial susceptibility patterns of community- and hospital-acquired methicillin-resistant Staphylococcus aureus from United States Hospitals: results from the AWARE Ceftaroline Surveillance Program (2012-2014)
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- 作者：Helio S. Sader ; helio-sader@jmilabs.com" class="auth_mail" title="E-mail the corresponding author ; Rodrigo E. Mendes ; Ronald N. Jones ; Robert K. Flamm
- 关键词：Skin and soft tissue infection ; Pneumonia ; Bacteremia
- 刊名：Diagnostic Microbiology & Infectious Disease
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：86
- 期：1
- 页码：76-79
- 全文大小：198 K
文摘
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Of 8437 methicillin-resistant Staphylococcus aureus (MRSA) isolates collected from 143 medical centers in the United States from January 2012 to December 2014, 7116 were reported as community-acquired (CA) and 1321 were reported as and hospital-acquired (HA) MRSA.
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Overall, susceptibility rates were generally lower among HA-MRSA compared to CA-MRSA strains, especially for clindamycin (44.6 vs. 66.1%) and levofloxacin (21.4 vs. 35.5%).
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Susceptibility rates were lower among isolates from pneumonia compared to skin and soft tissue infections and bacteremia.
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Ceftaroline was broadly active against 98.0% of CA-MRSA and 94.3% of HA-MRSA (MIC50/90, 1 μg/mL for both; no resistant isolate) overall, with little variation among infection type subsets.