Breast Cancer-Derived Lung Metastases Show Increased Pyruvate Carboxylase-Dependent Anaplerosis
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- 作者：Stefan Christen1 ; 2 ; Doriane Lorendeau1 ; 2 ; Roberta Schmieder1 ; 2 ; Dorien Broekaert1 ; 2 ; Kristine Metzger1 ; 2 ; Koen Veys3 ; Ilaria Elia1 ; 2 ; Joerg Martin Buescher1 ; 2 ; Martin Franz Orth4 ; Shawn Michael Davidson5 ; Thomas Georg Philipp Grü ; newald4 ; Katrien De Bock6 ; Sarah-Maria Fendt1 ; 2 ; 7 ; sarah-maria.fendt@vib-kuleuven.be" class="auth_mail" title="E-mail the corresponding author
- 关键词：pyruvate carboxylase ; mitochondrial pyruvate concentration ; lung metastasis ; breast cancer ; TCA cycle anaplerosis ; microenvironment ; glycolytic metabolism ; cancer metabolism ; 13C tracer analysis ; pyruvate metabolism
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：11 October 2016
- 年：2016
- 卷：17
- 期：3
- 页码：837-848
- 全文大小：3016 K
文摘
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Lung metastases have higher PC-dependent anaplerosis than primary breast cancers
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PC-dependent anaplerosis is a function of the in vivo microenvironment
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Pyruvate to glutamine availability is increased in the in vivo lung microenvironment
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Compartment-specific pyruvate distributions can be inferred from 13C labeling patterns