Synthesis and biological evaluation of methoxylated analogs of the newer generation taxoids IDN5109 and IDN5390
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- 作者：Luciano Barboni ; Roberto Ballini ; Guido Giarlo ; Giovanni Appendino ; Gabriele Fontana and Ezio Bombardelli
- 关键词：Paclitaxel ; IDN5109 ; IDN5390 ; Methoxylated ; Newer generation taxoids
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2005
- 出版时间：2005
- 年：2005
- 卷：15
- 期：23
- 页码：5182-5186
- 全文大小：159 K
文摘
Starting from 10-deacetylbaccatin III (7), the 2-debenzoyl-2-m-methoxybenzoyl analogs of the newer generation taxoids IDN5109 (3) and IDN5390 (4) were synthesized. The biological evaluation of these compounds (5 and 6, respectively) showed a general increase of cytotoxicity, as observed in first-generation anticancer taxanes.