Intake of jaboticaba peel attenuates oxidative stress in tissues and reduces circulating saturated lipids of rats with high-fat diet-induced obesity
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- 作者：脗ngela Giovana Batista ; Sabrina Alves Lenquiste ; Cinthia Ba煤 Betim Cazarin ; Juliana Kelly da Silva ; Anderson Luiz-Ferreira ; Stanislau Bogusz Jr. ; Le ; ro Wang Hantao ; Renato Nunes de Souza ; Fabio Augusto ; Marcelo Alex ; re Prado ; M谩rio Roberto Mar贸stica Jr.
- 关键词：Myrciaria jaboticaba (Vell.) Berg. ; Obesity ; Polyphenols ; Antioxidant defenses ; Lipid peroxidation ; Fatty acids methyl esters
- 刊名：Journal of Functional Foods
- 出版年：January, 2014
- 年：2014
- 卷：6
- 期：Complete
- 页码：450-461
- 全文大小：1033 K
文摘
The bioactive compounds of freeze-dried jaboticaba peel (FJP), serum lipids and the antioxidant status of rats fed high-fat diets containing different doses of FJP were evaluated. Obesity was induced and three groups of the obese animals received high-fat diet with 1%, 2% and 4% FJP added (J1, J2 and J4, respectively). The HPLC-DAD analyses of the polyphenols in the FJP showed four compounds: gallic acid, cyanidin 3-glucoside, ellagic acid, and quercetin. The serum saturated fatty acids were reduced in J1 and J4-fed animals. The antioxidant defenses of plasma were increased in the J2 and J4-fed animals. All the FJP diets prevented lipid peroxidation in the liver and increased its antioxidant defenses. Lipid peroxidation in brain decreased with an increasing FJP content in the diet. The antioxidant status of the kidneys of J2 and J4-fed animals increased. Thus, FJP could be an alternative to minimize the high-fat diet-induced oxidative stress and circulating saturated lipids.