Statins enhance circulating vitamin E

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• 作者：Roberto Cangemi ; Lorenzo Loffredo ; Roberto Carnevale ; Pasquale Pignatelli ; Francesco Violi
• 关键词：Oxidative stress ; Vitamin E ; Statin ; Metabolic syndrome
• 刊名：International Journal of Cardiology
• 出版年：2008
• 出版时间：11 January 2008
• 年：2008
• 卷：123
• 期：2
• 页码：172-174
• 全文大小：143 K

文摘

Statins have been shown to inhibit oxidative stress, however it is still unclear if they influence antioxidant status. We performed a retrospective analysis of oxidative stress, as assessed by serum levels of 8-hydroxy-2-deoxyguanosine (8-OHdG) and vitamin E, a known antioxidant, in patients with metabolic syndrome (n = 112) treated (n = 30) or not (n = 82) with statins. Statin-treated patients showed higher levels of vitamin E (p = 0.02) and lower 8-OHdG (p < 0.01) than statin-free patients. An inverse correlation between oxidative stress and vitamin E was observed (r = − 0.670, p < 0.001). These preliminary data suggest that statins enhance the antioxidant status likely by inhibiting oxidative stress.