Augmented renal clearance in critically ill patients: etiology, definition and implications for beta-lactam dose optimization

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• 作者：Fekade Bruck Sime¹ ; Andrew A Udy¹ ; ² ; ³ ; Jason A Roberts¹ ; ⁴ ; ^{j.roberts2@uq.edu.au" class="auth_mail" title="E-mail the corresponding author}
• 刊名：Current Opinion in Pharmacology
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：24
• 期：Complete
• 页码：1-6
• 全文大小：423 K

文摘

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d="par0005">Augmented renal clearance (ARC) is a prevalent condition in the critically ill.

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d="par0010">ARC may result in sub-therapeutic exposure of renally eliminated antibiotics.

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d="par0015">Beta-lactams are particularly affected due to their pharmacokinetic and pharmacodynamic characteristics.

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d="par0020">Dose optimization is necessary to circumvent the influence of ARC.

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d="par0025">Therapeutic drug monitoring may be necessary to guide dose optimization.

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