Effect of obesity on the pharmacokinetics of antimicrobials in critically ill patients: A structured review

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• 作者：Abdulaziz S. Alobaid^a ; Maya Hites^b ; Jeffrey Lipman^a ; ^c ; Fabio Silvio Taccone^d ; Jason A. Roberts^a ; ^c ; ^e ; ^{j.roberts2@uq.edu.au" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Antifungal ; Fluconazole ; Pharmacodynamics ; Non-obese patients ; Obesity ; Morbidly obese patients
• 刊名：International Journal of Antimicrobial Agents
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：47
• 期：4
• 页码：259-268
• 全文大小：1146 K

文摘

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d="par0005">Obesity is likely to cause alterations to antimicrobial pharmacokinetics (PK).

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d="par0010">Hydrophilic antimicrobials may display altered PK in obese critically ill patients.

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d="par0015">Loading doses of vancomycin should be based on total body weight in obese patients.

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d="par0020">In most studies standard dosage regimens of antimicrobials are sufficient to achieve pharmacodynamic targets.

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d="par0025">Larger antimicrobial doses may be required for pathogens with higher MICs.

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