Simultaneous determination of seven 尾-lactam antibiotics in human plasma for therapeutic drug monitoring and pharmacokinetic studies

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• 作者：Fekade Bruck Sime^a ; ^b ; ^{Fekade.Sime@mymail.unisa.edu.a" class="auth_mail} ; Michael S. Roberts^a ; ^b ; ^c ; ¹ ; ^{Michael.Roberts@unisa.edu.au" class="auth_mail} ; Jason A. Roberts^a ; ^d ; ^e ; ² ; ^{j.roberts2@uq.edu.au" class="auth_mail} ; Thomas A. Robertson^a ; ^b ; ³ ; ^{tomroberts@adam.com.au" class="auth_mail}
• 关键词：尾-lactam ; Antibiotics ; LC-MS/MS ; Therapeutic drug monitoring ; Pharmacokinetics
• 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
• 出版年：1 June 2014
• 年：2014
• 卷：960
• 期：Complete
• 页码：134-144
• 全文大小：1615 K

文摘

<dl class="listitem" id="list_lis0005"><dt class="label">•dt><dd>

d="par0005">We present a method for simultaneous determination of seven beta-lactams in plasma.

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d="par0010">The selected antibiotics are those commonly used in critically ill patients.

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d="par0015">The method is accurate, precise and meets validation requirements by guidelines.

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d="par0020">It proved applicable for therapeutic drug monitoring and pharmacokinetic studies.

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