Simultaneous determination of seven 尾-lactam antibiotics in human plasma for therapeutic drug monitoring and pharmacokinetic studies
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- 作者：Fekade Bruck Simea ; b ; Fekade.Sime@mymail.unisa.edu.a" class="auth_mail ; Michael S. Robertsa ; b ; c ; 1 ; Michael.Roberts@unisa.edu.au" class="auth_mail ; Jason A. Robertsa ; d ; e ; 2 ; j.roberts2@uq.edu.au" class="auth_mail ; Thomas A. Robertsona ; b ; 3 ; tomroberts@adam.com.au" class="auth_mail
- 关键词：尾-lactam ; Antibiotics ; LC-MS/MS ; Therapeutic drug monitoring ; Pharmacokinetics
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：1 June 2014
- 年：2014
- 卷：960
- 期：Complete
- 页码：134-144
- 全文大小：1615 K
文摘
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We present a method for simultaneous determination of seven beta-lactams in plasma.
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The selected antibiotics are those commonly used in critically ill patients.
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The method is accurate, precise and meets validation requirements by guidelines.
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It proved applicable for therapeutic drug monitoring and pharmacokinetic studies.