Induced sputum compared to bronchoalveolar lavage in young, non-expectorating cystic fibrosis children
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- 作者：Hannah Blau ; Barry Linnane ; Rosemary Carzino ; Esta-Lee Tannenbaum ; Billy Skoric ; Philip J. Robinson ; Colin Robertson ; Sarath C. Ranganathan
- 关键词：BAL ; bronchoalveolar lavage ; CF ; cystic fibrosis ; IS ; induced sputum ; URTF ; upper respiratory tract flora ; P. aeruginosa ; Pseudomonas aeruginosa ; S. aureus ; Staphylococcus aureus ; H. influenzae ; Haemophilus influenzae ; S. marcescens ; Serratia marcescens
- 刊名：Journal of Cystic Fibrosis
- 出版年：January, 2014
- 年：2014
- 卷：13
- 期：1
- 页码：106-110
- 全文大小：146 K
文摘
Background
Induced sputum (IS) is feasible and safe in young CF children and is a readily accessible, non-invasive technique. However, it has not been compared to bronchoalveolar lavage (BAL), the gold standard for diagnosing lower airway infection.Methods
We compared bacterial yield from IS and BAL in 11 non-expectorating CF children, aged 3 to 7.4 years. IS samples were obtained in 10/11 cases.
Results
Eight out of ten had the same predominant bacteria cultured from IS and BAL: Pseudomonas aeruginosa and Stenotrophomonas maltophilia , Staphylococcus aureus , and upper respiratory tract flora . In one, Serratia marcescens and Haemophilus parainfluenzae were cultured from IS alone, whereas in one, non-group B Haemophilus influenzae was cultured from BAL alone.
Conclusions
As proof of principle, IS samples showed good bacteriologic correlation with BAL. Larger studies are recommended to confirm IS as a clinically valuable tool and measure for early intervention studies in young CF children.