A flexible method for the synthesis of 2-substituted 1,2,5,6-tetrahydropyridines and piperidines from chloro-containing propargylamines

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• 作者：Danielle N. Penk¹ ; Nathan A. Robinson¹ ; Harrison M. Hill ; Mark Turlington ; ^{mturlington@berry.edu}
• 关键词：1 ; 2 ; 5 ; 6-Tetrahydropyridine ; Piperidine ; Stereoselective ; Propargylamine ; Azaheterocycle
• 刊名：Tetrahedron Letters
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：58
• 期：5
• 页码：470-473
• 全文大小：628 K
• 卷排序：58

文摘

The stereoselective synthesis of 1,2,5,6-tetrahydropyridines is described. Aryl, alkyl, and α,β-unsaturated substituents at the 2-position are reported. The methodology can be extended to the synthesis of 2-substituted piperidines.