Donor Lymphocyte Infusion-Mediated Graft-versus-Host Responses in a Preclinical Swine Model of Haploidentical Hematopoietic Cell Transplantation
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- 作者：Raimon Duran-Struuck1 ; 2 ; Rduranst@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Abraham J. Matar2 ; 3 ; Rebecca L. Crepeau2 ; Alexander G.S. Teague2 ; Benjamin M. Horner2 ; Vimukthi Pathiraja2 ; Thomas R. Spitzer4 ; Jay A. Fishman5 ; Roderick T. Bronson6 ; David H. Sachs2 ; Christene A. Huang2
- 关键词：Mixed chimerism ; MHC defined miniature swine ; Donor leukocyte infusion ; Lymphohematopoietic graft-versus- host responses ; Graft-versus-leukemia and graft-versus-host disease
- 刊名：Biology of Blood and Marrow Transplantation
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：22
- 期：11
- 页码：1953-1960
- 全文大小：484 K
文摘
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Mixed chimerism without GVHD across MHC barriers can be achieved in a RIC swine HCT model.
Mixed chimeras are highly resistant to delayed DLI GVH effects.
Pre-DLI leukodepletion overcomes resistance to conversion.
GVHD is often, but not always, observed after DLI conversion.