Long-term effects of cancer therapy in children - functional effects, late mortality and long-term follow-up

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• 作者：Roderick Skinner
• 关键词：cancer ; chemotherapy ; child ; late adverse effects ; leukaemia ; long-term follow-up ; radiotherapy ; survivorship ; transition
• 刊名：Paediatrics and Child Health
• 出版年：2012
• 出版时间：June, 2012
• 年：2012
• 卷：22
• 期：6
• 页码：248-252
• 全文大小：84 K

文摘

Although over 75 % of children with malignancy are cured by contemporary treatment protocols in developed countries, many survivors suffer from chronic side effects of treatment which may be severe or even life-threatening in 30 % . Such late adverse effects may result in disturbed childhood and adolescent growth and development, or have profound consequences on future health status, even resulting in premature death. Some groups of survivors are at even higher risk of multiple or serious toxicities, for example those treated for a central nervous system (CNS) tumour or with a haemopoietic stem cell transplant (HSCT).

The second part of this series of two reviews describes some of the chronic functional consequences of treatment for childhood and adolescent malignancy including impairment of neuropsychological, metabolic and immunological function, growth and quality of life. In addition, the increased risk of secondary malignant neoplasms and of late yet still premature mortality, and the nature of late toxicity in survivors of CNS tumours and HSCTs, will be highlighted. The development of appropriate long-term follow-up strategies intended to improve the health of long-term survivors will be described, and the growing focus on the provision of optimal long-term follow-up care and the quality of survivorship will be emphasized.