Insulin resistance influences central opioid activity in polycystic ovary syndrome
详细信息 查看全文
- 作者：Alison Berent-Spillson ; Tiffany Love ; Rodica Pop-Busui ; MaryFran Sowers ; Carol C. Persad ; Kathryn P. Pennington ; Aimee D. Eyvazaddeh ; Vasantha Padmanabhan ; Jon-Kar Zubieta ; Yol ; a R. Smith
- 关键词：Positron emission tomography ; glucose regulation ; μ ; -opioid receptors ; neuroimaging ; β ; -endorphins ; PCOS ; insulin resistance
- 刊名：Fertility and Sterility
- 出版年：2011
- 出版时间：30 June 2011
- 年：2011
- 卷：95
- 期：8
- 页码：2494-2498
- 全文大小：527 K
文摘
This pilot study describes a relationship between insulin resistance and μ-opioid neurotransmission in limbic appetite and mood-regulating regions in women with polycystic ovary syndrome (PCOS), suggesting that insulin–opioid interactions may contribute to behavioral and reproductive pathologies of PCOS. We found that [1] patients with PCOS who are insulin-resistant (n = 7) had greater limbic μ-opioid receptor availability (nondisplaceable binding potential) than controls (n = 5); [2] receptor availability was correlated with severity of insulin resistance; and [3] receptor availability normalized after insulin-regulating treatment.