- 作者：Courtney A. Marsh ; M.D. ; M.P.H.a ; rowlandc@umich.edu ; Alison Berent-Spillson ; Ph.D.b ; c ; Tiffany Love ; Ph.D.b ; c ; d ; Carol C. Persad ; Ph.D.c ; Rodica Pop-Busui ; M.D. ; Ph.D.e ; Jon-Kar Zubieta ; M.D. ; Ph.D.b ; c ; f ; Yolanda R. Smith ; M.D. ; M.S.a ; g
- 关键词：Emotion ; functional magnetic resonance ; insulin resistance ; imaging (fMRI) ; mu-opioid neurotransmission ; polycystic ovary syndrome (PCOS)
- 刊名：Fertility and Sterility
- 出版年：2013
- 出版时间：July, 2013
- 年：2013
- 卷：100
- 期：1
- 页码：200-207.e1
- 全文大小：968 K
Objective
To evaluate emotional processing in women with insulin-resistant polycystic ovary syndrome (IR-PCOS) and its relationship to glucose regulation and the mu-opioid system.Design
Case-control pilot.
Setting
Tertiary referring medical center.
Patient(s)
Seven women with IR-PCOS and five non-insulin-resistant controls, aged 21-40 years, recruited from the general population.
Intervention(s)
Sixteen weeks of metformin (1,500 mg/day) in women with IR-PCOS.
Main Outcome Measure(s)
Assessment of mood, metabolic function, and neuronal activation during an emotional task using functional magnetic resonance imaging (fMRI), and mu-opioid receptor availability using positive emission tomography (PET).
Result(s)
We found that insulin-resistant PCOS patients [1] had greater limbic activation during an emotion task than controls (n = 5); [2] trended toward decreased positive affect and increased trait anxiety; [3] after metformin treatment, had limbic activation that no longer differed from controls; and [4] had positive correlations between fMRI limbic activation during emotional processing and mu-opioid binding potential.
Conclusion(s)
Patients with IR-PCOS had greater regional activation during an emotion task than the controls, although this resolved with metformin therapy. Alterations in mu-opioid neurotransmission may underlie limbic system activity and mood disorders in IR-PCOS.
Clinical Trial Registration Number
.