• 作者：Carlos Ferná ; ndez-Viadero^a ; ^{cfdezviadero@ono.com} ; Eloy Rodr&#237 ; guez Rodr&#237 ; guez^b ; Onofre Combarros Pascual^c ; Dá ; maso Crespo Santiago^d
• 关键词：Alzheimer ; Genes ; Anciano
• 刊名：Revista Espa?ola de Geriatr¨ªa y Gerontolog¨ªa
• 出版年：2013
• 出版时间：January-February, 2013
• 年：2013
• 卷：48
• 期：1
• 页码：39-44
• 全文大小：660 K

The high prevalence of Alzheimer's disease, along with the possibility of new approaches in diagnosis through the use of biomarkers of cerebrospinal fluid is shifting the focus to the elderly with dementia or at risk. In this sense it seems important to review the genetic aspects of the elderly with familial Alzheimer's disease as well as those at risk. The wide distribution of genetic studies associated with this condition may also be helpful. To the classical findings of the genes for amyloid, the presenilins and apolipoprotein E, we must add other genes recently implicated in the pathogenesis of the disease, among which are found the clusterin gene, encoding the phosphatidyl-inositol-binding clathrin assembly protein gene, and the receptor for the complement C3b protein.