Bufadienolides from parotoid gland secretions of Cuban toad Peltophryne fustiger (Bufonidae): Inhibition of human kidney Na+/K+-ATPase activity
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- 作者：Wilmer H. Perera Có ; rdovaa ; Wilmer.Perera@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Suzana Guimarã ; es Leitã ; oa ; Geraldino Cunha-Filhob ; 1 ; Roberto Alonso Boschc ; Isel Pascual Alonsoc ; Rogelio Pereda-Mirandad ; Rodrigo Gervoub ; Natá ; lia Araú ; jo Touzab ; Luis Eduardo M. Quintasb ; Franç ; ois Noë ; lb
- 关键词：Peltophryne fustiger ; Western Giant toad ; Bufadienolides ; 1D and 2D NMR spectroscopy ; UPLC-MS/MS ; HRESIMS ; Na+/K+ ATPase
- 刊名：Toxicon
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：110
- 期：Complete
- 页码：27-34
- 全文大小：1020 K
文摘
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Ten metabolites were isolated from gland secretions of Peltophryne fustiger.
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Arenobufagin is the major bufadienolide in this toad secretion.
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Arenobufagin and bufalin were 100 times more potent than ψ-bufarenogin.