An efficient two-step synthesis of novel 2-amino-substituted pyrazolo[1,5-a][1,3,5]triazines

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• 作者：Henry Insuasty^a ; ^{hein@udenar.edu.co} ; Braulio Insuasty^b ; Edison Castro^a ; ^b ; Jairo Quiroga^b ; Rodrigo Abonia^b
• 关键词：5-Amino-1H-pyrazoles ; Pyrazolo[1 ; 5-a][1 ; 3 ; 5]triazines ; Pyrazolylthioureas ; Guanylation ; Nucleophilic amination ; Mercury(II) chloride
• 刊名：Tetrahedron Letters
• 出版年：2013
• 出版时间：27 March, 2013
• 年：2013
• 卷：54
• 期：13
• 页码：1722-1725
• 全文大小：364 K

文摘

A series of novel 2-amino-substituted pyrazolo[1,5-m>am>][1,3,5]triazines were selectively synthesized by a two-step reaction between 5-amino-3-hetaryl-1m>Hm>-pyrazoles and hetaroyl isothiocyanates with subsequent amination and cyclization promoted by the couple HgCl₂/TEA and DMF as solvent. This approach provided the title compounds in good to excellent yields and under mild reaction conditions. The structures of the new compounds were unambiguously established by spectroscopic and analytical techniques.