Mineral and organic amendments were applied to a multi metal[loid] contaminated mine soil [spoil] in a 90 day pot trial. Iron (Fe) based amendments reduced Cd and Cu concentrations in pore water furthest compared to the untreated mine spoil. Fe(II) + CaCO3 was highly efficient at reducing metal[loid] concentration in ryegrass tissue and increasing biomass yield. Phosphorus (P) based amendments generally had no significant impact on ryegrass biomass whilst compost mobilised As into pore water. Thus Fe(II) + CaCO3 amendment should be considered in field-remediation trials at the studied mine site.