A total of 558 consecutive patients undergoing primary PCI for STEMI via femoral route were studied for in-hospital outcomes through a prospective registry from January 2003 to December 2008. The primary end point was the presence of major vascular complication (MVC) defined as a composite of fatal access site bleeding, access site complication requiring interventional or surgical correction, or access site bleeding with ≥3 g/dL drop in hemoglobin or requiring blood transfusion.
Of the total patients, 464 (83.2 % ) received a VCD; and manual compression was used in 94 patients (16.8 % ). Major vascular complication occurred in 5.2 % of patients. The risk of MVC was significantly lower with VCDs compared with manual compression (4.3 % vs 9.6 % , P = .036). Multivariable logistic regression analysis determined that VCD use remained an independent predictor of lower rate of MVC (odds ratio 0.38, 95 % CI 0.17-0.91).
The use of VCDs in patients undergoing primary PCI for STEMI is safe and is associated with lower rates of MVC compared with manual compression.