Indoleamine-2,3-dioxygenase mediates neurobehavioral alterations induced by an intracerebroventricular injection of amyloid-β1-42 peptide in mice
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- 作者：Leandro Cattelan Souza ; Cristiano R. Jesse ; cristianoricardojesse@yahoo.com.br" class="auth_mail" title="E-mail the corresponding author ; Michelle S. Antunes ; Jossana Rodrigues Ruff ; Dieniffer de Oliveira Espinosa ; Nathalie Savedra Gomes ; Franciele Donato ; Renata Giacomeli ; Silvana Peterini Boeira
- 关键词：Alzheimer&rsquo ; s disease ; Neuroinflammation ; Indoleamine-2 ; 3-dyoxigenase ; Tryptophan ; Kynurerine ; Neurotrophic factor ; Memory ; Depression ; Anxiety
- 刊名：Brain, Behavior, and Immunity
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：56
- 期：Complete
- 页码：363-377
- 全文大小：1028 K
文摘
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Intracerebroventricular injection of Aβ1-42 induced memory and emotional disturbances.
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Aβ1-42 elicits neuroinflammation and neurotrophic deficiency in brain of mice.
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Aβ1-42 increased indoleamine-2,3-dioxygenase activity in brain of mice.
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Aβ1-42 increased tryptophan levels and kynurerine/tryptophan ratio in brain of mice.
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Indoleamine-2,3-dioxigenase mediates behavioral disturbances induced by Aβ1-42.