Protective action of ethanolic extract of Rosmarinus officinalis L. in gastric ulcer prevention induced by ethanol in rats

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• 作者：Guilherme Pires Amaral^a ; Nelson Rodrigues de Carvalho^a ; Rô ; mulo Pillon Barcelos^a ; Fernando Dobrachinski^a ; Rafael de Lima Portella^a ; Michele Hinerasky da Silva^a ; Thiago Henrique Lugokenski^a ; Glaecir Roseni Mundstock Dias^a ; Sô ; nia Cristina Almeida da Luz^a ; Aline Augusti Boligon^b ; Margareth Linde Athayde^b ; Marcos Antonio Villetti^c ; Fé ; lix Alexandre Antunes Soares^a ; ^{felix@ufsm.br} ; Roselei Fachinetto^d
• 关键词：eeRo ; ethanolic extract of Rosmarinus officinalis L. ; Omep ; omeprazole ; etOH ; ethanol
• 刊名：Food and Chemical Toxicology
• 出版年：2013
• 出版时间：May, 2013
• 年：2013
• 卷：55
• 期：Complete
• 页码：48-55
• 全文大小：1383 K

文摘

The pathology of a gastric ulcer is complex and multifactorial. Gastric ulcers affect many people around the world and its development is a result of the imbalance between aggressive and protective factors in the gastric mucosa. In this study, we evaluated the ethanolic extract of Rosmarinus officinalis L. (eeRo); this plant, more commonly known as rosemary, has attracted the interest of the scientific community due to its numerous pharmacological properties and their potential therapeutic applications. Here, we tested the preventive effects of eeRo against gastric ulcer induced by 70 % ethanol in male Wistar rats. In addition, we aimed to clarify the mechanism involved in the preventive action of the eeRo in gastric ulcers. Based on the analysis of markers of oxidative damage and enzymatic antioxidant defense systems, the measurement of nitrite and nitrate levels and the assessment of the inflammatory response, the eeRo exhibited significant antioxidant, vasodilator and antiinflammatory properties.