MRI to quantify early radiation-induced changes in the salivary glands

详细信息    查看全文

• 作者：Antonetta C. Houweling¹ ; Tim Schakel ; Cornelis A.T. van den Berg ; Marielle E.P. Philippens ; Judith M. Roesink ; Chris H.J. Terhaard ; Cornelis P.J. Raaijmakers  ; ;   ; ^{C.P.J.Raaijmakers@umcutrecht.nl} ;   ; ^{a.houweling@nki.nl}
• 关键词：MRI ; Oropharyngeal cancer ; Radiotherapy ; Xerostomia ; DCE-MRI
• 刊名：Radiotherapy and Oncology
• 出版年：2011
• 出版时间：September 2011
• 年：2011
• 卷：100
• 期：3
• 页码：386-389
• 全文大小：465 K

文摘

Purpose

We investigated radiation-induced changes in the salivary glands, 6 weeks after RT, using MRI.

Materials and methods

Eighteen oropharyngeal cancer patients were treated with salivary gland sparing IMRT. All patients received a 3T MRI exam before and 6 weeks after the end of RT, including a T_mlns="""">1-weighted (T_mlns="""">1w), a T_mlns="""">2-weighted (T_mlns="""">2w), and a dynamic contrast-enhanced (DCE) MRI.

For both time points separately, the parotid and submandibular glands were delineated on the MR images. Differences in median signal intensity and signal variation within the glands were tested for significance. Correlations were studied between the MR changes and the planned RT dose.

Results

The volume of the glands reduced significantly by 25 % . The T_mlns="""">1w signal decreased by 10 % and the T_mlns="""">2w signal increased by 23 % . The mlns="""">k_mlns="""">ep value decreased, while the mlns="""">v_mlns="""">e increased. A correlation of the changes in T_mlns="""">2w signal with the mean dose was found in both glands.

Conclusions

Overall radiation-induced changes and volume loss were observed in the parotid and submandibular gland using MR. The observed differences indicated an increased water content such as found in oedema. The overall changes could be related to the mean dose, with a slightly greater impact in the high dose area.