Lactobacillus plantarum CLP-0611 ameliorates colitis in mice by polarizing M1 to M2-like macrophages
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- 作者：Se-Eun Janga ; b ; Myung Joo Hanb ; Se-Young Kimc ; Dong-Hyun Kima ; dhkim@khu.ac.kr" class="auth_mail
- 关键词：LPS ; lipopolysaccharide ; LAB ; lactic acid bacteria ; TNBS ; 2 ; 4 ; 6-trinitrobenzene sulfonic acid ; IBD ; inflammatory bowel disease ; DSS ; dextran sulfate sodium ; IL ; interleukin ; TNF ; tumor necrosis factor ; NF-魏B ; NF-kappaB ; MAPK ; mitogen-activated protein kinase ; DMEM ; Dulbecco's modified Eagle's medium ; HTAB ; hexadecyl trimethyl ammonium bromide ; RIPA ; radioimmunoprecipitation assay ; ELISA ; enzyme-linked immunosorbent assay ; MRS ; de Man ; Rogosa and Sharpe ; CFU ; colony forming unit
- 刊名：International Immunopharmacology
- 出版年：July 2014
- 年：2014
- 卷：21
- 期：1
- 页码：186-192
- 全文大小：1261 K
文摘
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TNF-伪 production-inhibiting Lactobacillus plantarum CLP-0611 was isolated from kimchi.
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CLP0611 inhibited the expression of IL-1 and IL-6 as well as the activation of NF-魏B and AP1.
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CLP0611 inhibited colon shortening and myeloperoxidase activity in TNBS-induced colitic mice.
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CLP0611 inhibited NF-魏B and MAPK activation in TNBS-induced colitic mice.
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CLP0611 induced expression of M2 macrophage markers in TNBS-induced colitic mice.