Synthesis of polysubstituted 1,2-dihydroisoquinolines via a CuI-catalyzed arylation/condensation cascade process

详细信息    查看全文

• 作者：Yangyang Wu ; Yihua Zhang ; Yongwen Jiang ; Dawei Ma
• 刊名：Tetrahedron Letters
• 出版年：2009
• 出版时间：1 July 2009
• 年：2009
• 卷：50
• 期：26
• 页码：3683-3685
• 全文大小：290 K

文摘

CuI-catalyzed reaction of 1-(2-bromophenyl)-propargylamines 4 with β-keto esters in i-PrOH/H₂O (3:1) at 50 °C provides polysubstituted 1,2-dihydroisoquinolines. The transformation involves a cascade intermolecular C–C bond formation and intramolecular condensation process.