Functional genomics to discover antibiotic resistance genes: The paradigm of resistance to colistin mediated by ethanolamine phosphotransferase in Shewanella algae MARS 14
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- 作者：Amar A. Telke ; Jean-Marc Rolain ; jean-marc.rolain@univ-amu.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Shewanella algae MARS 14 ; Colistin resistance ; Functional genomics ; Ethanolamine phosphotransferase ; RT-PCR ; Lipopolysaccharide
- 刊名：International Journal of Antimicrobial Agents
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：46
- 期：6
- 页码：648-652
- 全文大小：608 K
文摘
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Resistance to colistin in Shewanella algae is mediated by expression of ethanolamine phosphotransferase (EptA).
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EptA is critical for modification of the outer membrane lipopolysaccharide conferring resistance to colistin.
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Functional genomics is an efficient approach to decipher the molecular support of antibiotic resistance.