Molecular mechanisms of polymyxin resistance: knowns and unknowns

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• 作者：Sophie Baron ; Linda Hadjadj ; Jean-Marc Rolain ; ^{jean-marc.rolain@univ-amu.fr} ; Abiola Olumuyiwa Olaitan ; ^{olaitanmuyi@gmail.com}
• 关键词：Colistin ; Polymyxin B ; mcr-1 ; Lipid A modification ; Antibiotic resistance
• 刊名：International Journal of Antimicrobial Agents
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：48
• 期：6
• 页码：583-591
• 全文大小：740 K
• 卷排序：48

文摘

Colistin is a last-line drug against multidrug-resistant Gram-negative pathogens. Chromosomal mutations and plasmid-borne mcr-1 remain the common modes of resistance. Not all mechanisms mediating colistin resistance are currently known.