Varenicline has antidepressant-like activity in the forced swim test and augments sertraline's effect
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- 作者：Hans Rollema ; Victor Guanowsky ; Yann S. Mineur ; Alka Shrikh ; e ; Jotham W. Coe ; Patricia A. Seymour ; Marina R. Picciotto
- 关键词：Forced swim test ; Varenicline ; Nicotinic acetylcholine receptor ; Partial agonist antidepressant
- 刊名：European Journal of Pharmacology
- 出版年：2009
- 出版时间：1 March 2009
- 年：2009
- 卷：605
- 期：1-3
- 页码：114-116
- 全文大小：198 K
文摘
Varenicline, an α4β2 nicotinic acetylcholine receptor partial agonist developed as a smoking cessation aid, showed antidepressant-like activity in the forced swim test in two mouse strains. In addition, a low varenicline dose significantly enhanced the effects of moderately active doses of the selective serotonin reuptake inhibitor sertraline. These findings are consistent with the notion that reducing α4β2 nicotinic acetylcholine receptor activity either by antagonists or by partial agonists that can partially activate or desensitize acetylcholine receptors is associated with antidepressant-like properties. These data suggest that varenicline may have antidepressant potential and can, when combined, augment antidepressant responses of selective serotonin reuptake inhibitors.