Peptidomics for the discovery and characterization of neuropeptides and hormones
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- 作者：Elena V. Romanova1 ; 2 ; Jonathan V. Sweedler1 ; 2 ; jsweedle@illinois.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：bioinformatics ; endogenous peptides ; sequencing ; mass spectrometry ; nervous system ; quantitation
- 刊名：Trends in Pharmacological Sciences
- 出版年：2015
- 出版时间：September 2015
- 年：2015
- 卷：36
- 期：9
- 页码：579-586
- 全文大小：799 K
文摘
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Alternative splicing and post-translational processing challenge neuropeptide prediction.
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MS sequences and quantifies neuropeptides directly in tissues and cells.
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Synergy of MS, genomics, and bioinformatics drives neuropeptide discovery.