Noise enhanced the electrical stimulation-contractile response coupling in isolated mouse heart

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• 作者：Alberto Peñ ; a-Romo ; Ana Marí ; a Gá ; mez-Mé ; ndez ; Amelia Rí ; os ; Bruno A. Escalante ; Jesú ; s Rodrí ; guez-Gonzá ; lez ; ^{jrodriguez@cinvestav.mx" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Synchronization ; Modes of synchronization ; Noise ; Stochastic resonance
• 刊名：International Journal of Cardiology
• 出版年：2016
• 出版时间：15 October 2016
• 年：2016
• 卷：221
• 期：Complete
• 页码：155-160
• 全文大小：1295 K

文摘

Stochastic resonance is a phenomenon that allows a system to improve its capability to detect stimulus when a limited amount of noise is added to the stimuli. It has experimentally been shown that noise enhances the homeostatic function of the blood pressure regulatory system. This study aimed to investigate whether the noise can enhance the contractile response in the whole heart.

Methods

Experiments were conducted in isolated mouse hearts (0.040 kg, n = 8), a Langendorff heart preparation is used to obtain two variables of the contractile response contraction force and heart rate. The contractile response due to an electrical stimulation perturbed with Gaussian noise was recorded.

Results

The results show that the intensity of noise induced in the electrical stimuli has an effect on the electrical stimulation-contractile response coupling. With 10% noise induced, the bandwidth where the synchronization effect is presented was increased from (7–11 Hz) to (6–12 Hz), and the irregular dynamic threshold was changed to 13 Hz.

Conclusions

We find that the noise increases the synchronization bandwidth in the electrical stimulation-contractile response coupling. We have experimentally demonstrated the stochastic resonance in isolated mouse heart.