Role of neurodevelopment involved genes in psychiatric comorbidities and modulation of inflammatory processes in Alzheimer's disease
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- 作者：Porcelli Stefanoa ; Crisafulli Concettab ; Donato Luigib ; Calabrò ; Marcob ; Politis Antonisc ; Liappas Ioannisc ; Albani Diegod ; Atti Anna Ritaa ; Salfi Raffaelea ; Raimondi Ilariad ; Forloni Gianluigid ; Papadimitriou George N.c ; De Ronchi Dianaa ; Serretti Alessandroa ; alessandro.serretti@unibo.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：Alzheimer's disease ; Genetics ; Neurodevelopment ; Inflammation ; Psychosis ; Depression
- 刊名：Journal of the Neurological Sciences
- 出版年：2016
- 出版时间：15 November 2016
- 年：2016
- 卷：370
- 期：Complete
- 页码：162-166
- 全文大小：249 K
文摘
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Alzheimer's disease (AD) etiopathogenesis involves neurodevelopmental processes.
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Variants within neurodevelopment related genes may be associated with AD.
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Investigating several variants within these genes, we did not find any association with AD.
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Some variants were associated with psychiatric symptoms and inflammation parameters.
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These genes may modulate specific symptoms of AD, maybe through a modulation of inflammation system.