Acute eosinophilic pneumonia caused by camostat mesilate: The first case report

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• 作者：Shinichiro Ota^a ; Yu Hara^a ; ^b ; ^{bronchiole0723@yahoo.co.jp" class="auth_mail" title="E-mail the corresponding author} ; Soichiro Kanoh^a ; Masahiro Shinoda^b ; Shuichi Kawano^a ; Yuji Fujikura^a ; Akihiko Kawana^a ; Masaharu Shinkai^a ; ^b
• 关键词：Camostat mesilate ; Drug cessation ; Drug-induced lung injury ; Drug lymphocyte stimulation test ; Eosinophilic pneumonia
• 刊名：Respiratory Medicine Case Reports
• 出版年：2016
• 出版时间：2016
• 年：2016
• 卷：19
• 期：Complete
• 页码：21-23
• 全文大小：738 K

文摘

Camostat mesilate is in widespread clinical use mainly to treat chronic pancreatitis, and drug-induced lung injury has not been previously reported. However, pulmonary infiltration with peripheral blood eosinophilia appeared after taking camostat mesilate for ten days. The histological findings showed eosinophilic infiltration into the alveolar space and interstitum, and drug lymphocyte stimulation test of peripheral blood was positive. Both peripheral blood eosinophilia and pulmonary involvements improved two weeks later with the cessation of this drug. To the best of our knowledge, this case is the first report of camostat mesilate-induced acute eosinophilic pneumonia.