Auto Poisoning of the Respiratory Chain by a Quorum-Sensing-Regulated Molecule Favors Biofilm Formation and Antibiotic Tolerance
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- 作者：Ronen Hazan1 ; 2 ; 3 ; 7 ; Yok Ai Que1 ; 2 ; 3 ; 8 ; Damien Maura1 ; 2 ; 3 ; Benjamin Strobel1 ; 2 ; Paul Anthony Majcherczyk4 ; Laura Rose Hopper1 ; 2 ; David J. Wilbur5 ; Teri N. Hreha6 ; Blanca Barquera6 ; Laurence G. Rahme1 ; 2 ; 3 ; rahme@molbio.mgh.harvard.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Current Biology
- 出版年：2016
- 出版时间：25 January 2016
- 年：2016
- 卷：26
- 期：2
- 页码：195-206
- 全文大小：2406 K
文摘
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HQNO triggers beneficial autolysis, promoting bacterial fitness
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HQNO inhibits bacterial respiration via the cytochrome bc1 complex
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bc1 complex inhibition reduces membrane potential and integrity
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Bacterial autolysis shares mechanistic similarities with eukaryotic apoptosis