Stimulation of Slack K+ Channels Alters Mass at the Plasma Membrane by Triggering Dissociation of a Phosphatase-Regulatory Complex
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- 作者：Matthew R. Fleming1 ; Maile R. Brown1 ; Jack Kronengold1 ; Yalan Zhang1 ; David P. Jenkins1 ; Gulia Barcia4 ; Rima Nabbout4 ; Anne E. Bausch5 ; Peter Ruth5 ; Robert Lukowski5 ; Dhasakumar S. Navaratnam2 ; Leonard K. Kaczmarek1 ; 3 ; 6 ; leonard.kaczmarek@yale.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：30 August 2016
- 年：2016
- 卷：16
- 期：9
- 页码：2281-2288
- 全文大小：2168 K
文摘
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Mutations in Slack K+ channels result in childhood epilepsy with intellectual disability
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Slack interacts with the protein phosphatase 1 (PP1) targeting protein Phactr1
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Channel phosphorylation dissociates the Phactr1/PP1 cytoplasmic signaling complex
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Slack/Phactr1 signaling is dysregulated in epilepsy-associated Slack channel mutants