Sesquiterpenoids from Curcuma wenyujin dreg and their biological activities

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• 作者：Hui-Feng Huang^a ; ^b ; ¹ ; Cai-Juan Zheng^a ; ¹ ; Guang-Ying Chen^a ; ^{chgying123@163.com" class="auth_mail" title="E-mail the corresponding author} ; Wen-Qing Yin^b ; ^{yinwq0000@aliyun.com" class="auth_mail" title="E-mail the corresponding author} ; Xian Huang^c ; Zheng-Rong Mo^a
• 关键词：Curcuma wenyujin dreg ; Sesquiterpenoids ; Antibacterial activity ; Antifungal activity
• 刊名：Chinese Chemical Letters
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：27
• 期：10
• 页码：1612-1616
• 全文大小：460 K

文摘

Four new sesquiterpenoids, 4,8-dioxo-6β-hydroxyl-7β,11-epoxycarabrane (rong class="boldFont">1rong>), 4,8-dioxo-6β-hydroxyl-7α,11-epoxycarabrane (rong class="boldFont">2rong>), wenyujinins Q and R (rong class="boldFont">3–4rong>), and nine known sesquiterpenoids (rong class="boldFont">5–13rong>) were isolated from the Curcuma wenyujin (C. wenyujin) dreg. Their structures and relative configurations were elucidated using 1D, 2D NMR, and HR-ESI-MS data. All the compounds were isolated for the first time from the C. wenyujin dreg and evaluated for their antibacterial and antifungal activities. Compounds rong class="boldFont">3rong>, rong class="boldFont">5rong>–rong class="boldFont">8rong> exhibited strong broad-spectrum antifungal activities against tested nine pathogenic fungi.