Aptamer-conjugated nanomaterials and their applications

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• 作者：Liu  ; Yang ; Xiaobing  ; Zhang ; Mao  ; Ye ; Jianhui  ; Jiang ; Ronghua  ; Yang ; Ting  ; Fu ; Yan  ; Chen ; Kemin  ; Wang ; Chen  ; Liu ; Weihong  ; Tan ;   ; ^{tan@chem.ufl.edu}
• 关键词：Aptamers ; Nanomaterials ; Biosensors ; Drug delivery
• 刊名：Advanced Drug Delivery Reviews
• 出版年：2011
• 出版时间：November 2011
• 年：2011
• 卷：63
• 期：14-15
• 页码：1361-1370
• 全文大小：1081 K

文摘

The combination of aptamers with novel nanomaterials, including nanomaterial-based aptamer bioconjugates has attracted considerable interest and has led to a wide variety of applications. In this review, we discuss how a variety of nanomaterials, including gold, silica and magnetic nanoparticles, as well as carbon nanotubes, hydrogels, liposomes and micelles, have been used to functionalize aptamers for a variety of applications. These aptamer functionalized materials have led to advances in amplified biosensing, cancer cell-specific recognition, high-efficiency separation, and targeted drug delivery.