Seed-targeting anti-miR-21 inhibiting malignant progression of retinoblastoma and analysis of their phosphorylation signaling pathways
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- 作者：Yong Dinga ; 1 ; Min Wua ; 1 ; Junzhong Liua ; Chunyun Wub ; Ruojing Huanga ; Rongxuan Zhuc ; Jia Feic ; efeijia@163.com" class="auth_mail
- 关键词：microRNA-21 ; seed-targeting ; tiny anti-miRNA ; retinoblastoma ; cell migration ; colony formation ; phosphorylation signaling pathway ; KEGG
- 刊名：Experimental Eye Research
- 出版年：May 2014
- 年：2014
- 卷：122
- 期：Complete
- 页码：1-8
- 全文大小：1676 K
文摘
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We first reported the high level expression of miR-21 as oncomiR in retinoblastoma cells.
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Seed-targeting t-antimiR-21 had an inhibitory effect on malignant progression in retinoblastoma cells.
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The phosphorylation signal, down-regulated by t-anti-miR-21, was involved in 14 cancer-related pathways in retinoblastoma.