The ROP18 and ROP5 gene allele types are highly predictive of virulence in mice across globally distributed strains of Toxoplasma gondii
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- 作者：Elliot Keats Shwaba ; Tiantian Jianga ; Hilda F.J. Penab ; Solange M. Gennarib ; Jitender P. Dubeyc ; Chunlei Sua ; csu1@utk.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Toxoplasma gondii ; Virulence ; ROP18 ; ROP5 ; ROP16 ; ROP17 ; Genotyping
- 刊名：International Journal for Parasitology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：46
- 期：2
- 页码：141-146
- 全文大小：863 K
文摘
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A diversity of alleles for the rhoptry protein encoding genes ROP18, ROP5, ROP16 and ROP17 exist.
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RFLP genotyping can readily be used to distinguish allele types among these genes.
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Alleles of the ROP18 and ROP5 loci correlate strongly with the virulence of <em>Toxoplasma gondiiem> strains.
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RFLP typing of ROP18 and ROP5 loci may be used to identify potentially virulent strains.