Human and murine prostate basal/stem cells are not direct targets of prolactin
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- 作者：Lucila Sackmann-Salaa ; 1 ; lucila.sackmann-sala@inserm.fr" class="auth_mail" title="E-mail the corresponding author ; Antoine Angelerguesa ; c ; 1 ; antoine.angelergues@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Florence Boutillona ; Bruno d&rsquo ; Acremontb ; brdacrem@club-internet.fr" class="auth_mail" title="E-mail the corresponding author ; Marc Maidenbergb ; maidenberg@wanadoo.fr" class="auth_mail" title="E-mail the corresponding author ; Sté ; phane Oudardc ; stephane.oudard@egp.aphp.fr" class="auth_mail" title="E-mail the corresponding author ; Vincent Goffina ; vincent.goffin@inserm.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：BPH ; benign prostate hyperplasia ; CK ; cytokeratin ; Erk1/2 ; extracellular signal-regulated kinase 1/2 ; Lin ; lineage ; MTT ; thiazolyl blue tetrazolium bromide ; Stat ; signal transducer and activator of transcription ; Sca-1 ; stem cell antigen 1 ; Trop2 ; tumor-associated calcium signal transducer 2
- 刊名：General and Comparative Endocrinology
- 出版年：2015
- 出版时间：1 September 2015
- 年：2015
- 卷：220
- 期：Complete
- 页码：133-142
- 全文大小：2937 K
文摘
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Prolactin induces amplification of basal/stem cells in the mouse prostate.
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We cultured basal/stem cells harvested from fresh mouse and human prostate tissues.
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Prolactin failed to trigger any biological response (signaling, self-renewal, etc.).
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We conclude that prostate basal/stem cells are not direct targets of prolactin.